"This calamity was neither to be introduced by one man, nor to terminate in one man…. Second Thessalonians 2:3; Daniel 7:9. Moreover, when the mark by which he [Paul] distinguishes Antichrist is that he would rob God of His honour and take it to himself…, it is certain that the Roman Pontiff has impudently transferred to himself the most peculiar properties of God and Christ. There cannot be a doubt that he is the leader and standard-bearer of an impious and abominable kingdom."
Paul himself deals with this in detail, in his own inspired discussion of Daniel's predictions — in Second Thessalonians 2:2-8. There, Calvin gives us the following vital insights on the many events which would follow the destruction of the Pagan Roman Empire — before the second advent (or coming again of Christ in final judgment).